List relevant preclinical models in biomedical research.
Cite the European and French regulations governing the housing and procedures on animals used for scientific purposes.
Identify the ethical issues of biomedical research on animal models.
Cite innovative alternative or complementary tools to animal research, listing their benefits, limitations, and integration into the trajectory of medical innovation; list principles for a balanced debate.
Content
Animal research for scientific purposes: history of comparative animal and human pathology – Christophe Degueurce (EnvA)
Alternative in vitro models: cells, organoids, organs-on-chip – Laurent Boyer, Muriel Coulpier (EnvA, Inrae, ANSES), Delphine Leroux (EnvA)
Animal models in research: informed choice, added value, and complementarity
Invertebrate models: BIPAR (EnvA) + Ilke Sen (IMRB)
Vertebrate models: Laurent Tiret (EnvA)
Primate models: Cécile Tuloup (Strasbourg)
Ethics and animal experimentation – Guillemette Crépeaux (EnvA)
Regulation of animal experimentation – Guillemette Crépeaux (EnvA)
Implementation of the 3Rs: presentation of French initiatives (FC3R) – Athanassia Sotiropoulos
Tools for creating genetically modified organisms (2 sessions) – Cochin
Illustration of the impact of animal research on human health: neuromuscular disorders
Preclinical evaluation of innovative gene, cell, and pharmacological therapies for Duchenne muscular dystrophy and congenital myopathies – Inès Barthélemy (EnvA)
From donor to patient: the Téléthon's chain of hope, between family support and collaborative research dynamics – Serge Braun (AFM)
Society and animal research (GIRCOR or Poma UPEC)
Tools for citizen communication between medical progress stakeholders and animal welfare advocates – To be determined (GIRCOR)
In silico modeling and artificial intelligence: tools for progressive replacement and reduction of animals in research – To be determined
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