A Two-Step Frailty Assessment Strategy in Older Patients With Solid Tumors: A Decision Curve Analysis

González Serrano A, Laurent M, Barnay T, Martínez-Tapia C, Audureau E, Boudou-Rouquette P, Aparicio T, Rollot-Trad F, Soubeyran P, Bellera C, Caillet P, Paillaud E, Canouï-Poitrine F. A Two-Step Frailty Assessment Strategy in Older Patients With Solid Tumors: A Decision Curve Analysis. J Clin Oncol. 2023 Feb 1;41(4):826-834. doi: 10.1200/JCO.22.01118. Epub 2022 Oct 28. PMID: 36306481; PMCID: PMC9901978.

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Key Objective

"Typically, the clinical value of screening tools relies on diagnostic accuracy measures such as sensitivity and specificity. However, it is unclear which accuracy level justifies tests' implementation or leads to decisions that would do more harm than good. In older patients with cancer, the recommendation of using frailty screening tools to identify patients who should undergo geriatric assessment (GA) relies on the diagnostic accuracy of screening tools. However, their clinical utility has not been verified."